Vantas (histrelin acetate) — ENDO PHARM INC.

Advanced prostatic carcinoma
50 mg (65 mcg/day) implant kit
Dosage information is not available

50 mg (50 mcg/day) implant kit
Dosage information is not available

Severe Warnings
Chronic heart failure
Congenital long QT syndrome
Hypokalemia
Hypomagnesemia
Prolonged QT interval
Contraindicated
Pregnancy
Moderate Warnings
Acute myocardial infarction
Cerebrovascular accident
Diabetes mellitus
Hypercholesterolemia
Hypertension
Increased cardiovascular event risk
Obesity
Tobacco smoker
Vertebral metastases
Less Frequent
Severe
Depression
Pain

Less Severe
Constipation
Dizziness
Erectile dysfunction
Erythema
Genital organ pruritus
Gynecomastia
Headache disorder
Hematoma
Increased urinary frequency
Insomnia
Libido changes
Skin inflammation
Testicular atrophy
Tremor
Weight gain
More Frequent
Severe
None

Less Severe
Bruising
Drug-induced hot flash
Fatigue
Flushing
Treatment site sequelae
Rare / Very Rare
Severe
Abnormal hepatic function tests
Acute myocardial infarction
Anemia
Arthralgias
Back pain
Body fluid retention
Bone pain
Cerebrovascular accident
Diabetes mellitus
Disease of liver
Dyspnea
Dysuria
Hematuria
Hypercalcemia
Kidney disease with reduction in GFR
Kidney stone
Mastalgia
Myalgias
Neck pain
Palpitations
Pituitary apoplexy
Pruritus of skin
Seizure disorder
Spinal cord compression
Tonic clonic seizure
Twitching
Urinary retention
Ventricular premature beats

Less Severe
Abnormal sexual function
Acute abdominal pain
Dysmenorrhea
General weakness
Hypercholesterolemia
Hyperglycemia
Hyperhidrosis
Increased appetite
Infection
Irritability
Lethargy
Limb pain
Malaise
Nausea
Night sweats
Peripheral edema
Sensation of cold
Skin swelling
Weight loss
More information
Contraindicated
None

Severe Precaution
Histrelin
1 Day – 2 Years
No safety and efficacy age < 2 years. Not recommended.

Management or Monitoring Precaution
None
Histrelin
Severity Level: 1
Additional Notes: Based on drug pharmacology developmental toxicity is possible.

More information
Contraindicated
None

Precaution Exists
Histrelin
GeneralExcretion PotentialEffect on InfantNotes
Evaluate use carefullyUnknownNot known; no or inclusive dataInsufficient data available

No Known Risk
None
More information
No precaution information has been provided for this patient type.
Advanced prostatic carcinoma
C61Malignant neoplasm of prostate
C61 Malignant neoplasm of prostate

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Diagnosis codes are provided for reference only. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatement.